Dyslipidemia And Coronary Artery Disease Pdf


By Tiffany O.
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05.12.2020 at 19:51
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dyslipidemia and coronary artery disease pdf

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Dyslipidemia is a primary, widely established as an independent major risk factor for coronary artery disease CAD.

The cardiovascular CV risk related to lipid disorders is well established and is based on a robust body of evidence from well-designed randomized clinical trials, as well as prospective observational studies. In the last two decades, significant advances have been made in understanding the genetic basis of dyslipidemias. The present review is intended as a comprehensive discussion of current knowledge about the genetics and pathophysiology of disorders that predispose to dyslipidemia.

Primary Prevention of CVD: Treating Dyslipidemia

Dyslipidemia, defined as elevated total or low-density lipoprotein LDL cholesterol levels, or low levels of high-density lipoprotein HDL cholesterol, is an important risk factor for coronary heart disease CHD and stroke. The incidence of dyslipidemia is high: In , approximately 25 percent of adults in the United States had total cholesterol greater than There is a continuous, graded relationship between the total plasma cholesterol concentration and ischemic heart disease morbidity and mortality. Ischemic heart disease is the leading single cause of death in high-income countries and the second in low- and middle-income countries. Primary prevention in this context is defined as long-term management of persons at increased risk, but who have no clinically overt evidence of cardiovascular disease CVD , such as myocardial infarction MI , angina, stroke, and peripheral vascular disease, and who have not undergone revascularization.

Cardiovascular disease CVD is a class of diseases that involve the heart or blood vessels. The underlying mechanisms vary depending on the disease. Cardiovascular diseases are the leading cause of death worldwide except Africa. There are many cardiovascular diseases involving the blood vessels. They are known as vascular diseases. There are many risk factors for heart diseases: age, sex, tobacco use, physical inactivity, excessive alcohol consumption, unhealthy diet, obesity, genetic predisposition and family history of cardiovascular disease, raised blood pressure hypertension , raised blood sugar diabetes mellitus , raised blood cholesterol hyperlipidemia , undiagnosed celiac disease , psychosocial factors, poverty and low educational status, and air pollution. Genetic factors influence the development of cardiovascular disease in men who are less than 55 years old and in women who are less than 65 years old.

Cardiovascular disease

Metrics details. Dyslipidemia may be defined as increased levels of serum total cholesterol TC , low-density lipoprotein cholesterol LDL-C , triglycerides TG , or a decreased serum high-density lipoprotein cholesterol HDL-C concentration. Dyslipidemia is an established risk factor for cardiovascular disease CVD. We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. However, after adjusting for confounding factors age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus , a significant direct association only remained between TC and MI risk in men HR: 2. In the present study, TC baseline level was significantly associated with the risk of MI among men.

Primary Prevention of CVD: Treating Dyslipidemia

Strategies aimed at primary prevention provide an outstanding opportunity for reducing the onset and burden of cardiovascular CV disease. Lipid abnormalities, including high levels of low-density lipoprotein cholesterol LDL-C , elevated triglycerides and low levels of high-density lipoprotein cholesterol HDL-C , are associated with an increased risk of CV events, thereby serving as contributors to this process. By consensus, lowering LDL-C, generally with statin therapy, is the primary target of lipid-lowering therapy. However, statin therapy may be insufficient for patients with mixed dyslipidemia, especially those with insulin resistance syndromes. While the addition of niacin, fibrate or omega-3 fatty acids may be useful in this setting, outcomes data are lacking.

Cardiovascular Disease and Dyslipidemia in Women

Despite the importance of identifying and screening dyslipidemia to prevent coronary artery diseases CAD Coronary Artery Disease , little information is available on dyslipidemia in our large area. So the present study aimed to assess the management status of lipid abnormalities and its association with other CAD risk factors in an urban population of southeast of Iran.

Dyslipidemia and cardiovascular disease risk among the MASHAD study population

The association between common dyslipidemias combined hyperlipidemia, simple hypercholesterolemia, metabolic Syndrome MetS , isolated low high-density lipoprotein cholesterol, and isolated hypertriglyceridemia compared with normolipidemia and the risk of multivessel CAC is underinvestigated. Objectives To determine whether there is an association between common dyslipidemias compared with normolipidemia, and the extent of coronary artery involvement among MESA participants who were free of clinical cardiovascular disease at baseline. Multivessel CAC was defined as involvement of at least 2 coronary arteries. Multivariate Poisson regression analysis evaluated the association of each group with multivessel CAC after adjusting for CVD risk factors. Results Unadjusted analysis showed that all groups except hypertriglyceridemia had statistically significant prevalence ratios of having multivessel CAC as compared to the normolipidemia group. The same groups maintained statistical significance prevalence ratios with multivariate analysis adjusting for other risk factors including Agatston CAC score [combined hyperlipidemia 1. These findings may lay the groundwork for further analysis of the underlying mechanisms in the observed relationship, as well as for the development of clinical strategies for primary prevention.

Welty FK. Cardiovascular Disease and Dyslipidemia in Women. Arch Intern Med.


Cardiology ; Dyslipidemia and Coronary Artery Disease. Prevalence and Treatment in Patients Referred for Coronary.


Coronary Artery Disease - Coronary Heart Disease

Associated Content

The association between common dyslipidemias combined hyperlipidemia, simple hypercholesterolemia, metabolic Syndrome MetS , isolated low high-density lipoprotein cholesterol, and isolated hypertriglyceridemia compared with normolipidemia and the risk of multivessel CAC is underinvestigated. To determine whether there is an association between common dyslipidemias compared with normolipidemia, and the extent of coronary artery involvement among MESA participants who were free of clinical cardiovascular disease at baseline. Multivessel CAC was defined as involvement of at least 2 coronary arteries. Multivariate Poisson regression analysis evaluated the association of each group with multivessel CAC after adjusting for CVD risk factors. Unadjusted analysis showed that all groups except hypertriglyceridemia had statistically significant prevalence ratios of having multivessel CAC as compared to the normolipidemia group. The same groups maintained statistical significance prevalence ratios with multivariate analysis adjusting for other risk factors including Agatston CAC score [combined hyperlipidemia 1. These findings may lay the groundwork for further analysis of the underlying mechanisms in the observed relationship, as well as for the development of clinical strategies for primary prevention.

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Becky A.
11.12.2020 at 04:54 - Reply

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