Inflammation Atherosclerosis And Coronary Artery Disease Pdf


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inflammation atherosclerosis and coronary artery disease pdf

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2018, Number 6

Our knowledge of the pathophysiology of atherosclerosis and the development of acute coronary syndrome ACS has progressed over the last few decades thanks to the large number of studies on the proliferation of smooth muscle cells, growth factors, and the biology of the vascular bed. The prominent role played by inflammation in the pathogenesis of atherosclerosis has become apparent over the last decade. The role of inflammation at the start of atherosclerotic processes and during their progression and in the complications present in the plaques has been well established through many clinical and experimental studies. On the other hand, investigation of different pathways and identification of what triggers this inflammatory process may unveil new therapeutic targets. The action of cytokines and other biomolecules and cells characteristic of inflammation is implicated in all stages of atherosclerosis, and so such molecules and cells have been considered as potential markers to identify and monitor the different stages of the disease. In recent years, a number of studies have correlated different biomarkers with cardiovascular disease, 3 leading to a rapid increase in the number of biomarkers available. Biomarkers must have certain characteristics to be a potential predictor of incident or prevalent coronary disease.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Lancet, Circulation, 5

Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between chronic infections and atherosclerosis triggered interest in a clinical association between these conditions. Various infectious microbes have been linked to atherosclerotic vascular disease in epidemiological studies. Identification of underlying pathophysiological mechanisms and experience with vaccination against various infectious agents has ushered a new avenue of efforts in the development of an anti-atherosclerotic vaccine. Studies in animal models have identified various innate and adaptive immune pathways in atherosclerosis. In this review, we discuss the patho-biological link between chronic infections and atherosclerosis, evaluate existing evidence of animal and human trials on the association between infections and cardiovascular disease and introduce the concept of an anti-atherosclerotic vaccine. Atherosclerosis is now considered a chronic inflammatory disease.

Inflammation, atherosclerosis, and coronary artery disease

Key words:. Global, regional, and national age-sex specific all-cause and cause-specific mortality for cau of death, a systematic analysis for the Global Burden of Disease Study Lancet London, England [Internet] ; Circulation [Internet] ; 25 Circulation [Internet] ; 25 Suppl 2 :S

Inflammation, atherosclerosis, and coronary artery disease.

Atherosclerosis is a multifactorial disease triggered and sustained by different risk factors such as dyslipidemia, arterial hypertension, diabetes mellitus, smoke, etc. Since a couple of decades, a pivotal role for inflammation in its pathogenesis has been recognized and proved at molecular levels, and already described in many animal models. Despite all this knowledge, due to the complexity of the specific inflammatory process subtending atherosclerosis and to the fact that inflammation is also a protective response against microorganisms, no anti-inflammatory therapy has been rendered available in the therapeutic armamentarium against atherosclerosis and vascular events till when canakinumab in the first ad-hoc randomized clinical trial RCT proved for the first time that targeting specifically inflammation lowers cardiovascular CV events. From the genetic side, in the 90's and early , several genetic markers in inflammatory pathway have been explored searching for an association with athero-thrombosis which gave seldom consistent results.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Immune cells dominate early atherosclerotic lesions, their effector molecules accelerate progression of the lesions, and activation of inflammation can elicit acute coronary syndromes.

Coronary Artery Disease (CAD)

MeSH terms

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PDF | ecent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of.

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