Textbook Of Basic And Clinical Immunology Pdf

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textbook of basic and clinical immunology pdf

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Essential Clinical Immunology begins with the basic concepts and then details the immuno-logical aspects of various disease states involving major organs of the body. Fast Download speed and ads Free!

Haemopoiesis is the process by which all cells that circulate in the blood arise and mature. Bosophils "which blue staining granules" 0.

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Clinical Immunology

Haemopoiesis is the process by which all cells that circulate in the blood arise and mature. Bosophils "which blue staining granules" 0.

They circulate in the blood and migrate into tissues particularly during inflammatory response. Their precursore unidentified possibly in spleen, thymus and lymph nodes. Large mononuclear cells. They have short half life, usually 24 hrs in blood then they become resident in tissues and become macrophages. Specialized forms of mature cells exist including alveolar macrophages in the lung, Kupffer cells in the liver, mesangial cells in the kidney, microglial cells in the brain, osteoclasts in bone and other macrophages lining channels in the spleen and lymph nodes.

They are bone marrow derived. They have cytoplasmic processes. They have specialized function in activation of lymphocytes.

They are some specialized forms of these cells e. They are found in the blood, lymphoid organs, or tissues and at sites of chronic inflammation. They are two subtypes:. B and T lymphocytes present in the blood in a ratio of 1 : 5. They can be differentiated by highly specialized molecules on their surfaces. Their precursors arise in the bone marrow and mature in two pathways: B cells: "antibody forming, bursa derived B cells".

They mature and differentiate in the bone marrow before being released in circulation. They recognize macromolecules "antigens" through surface receptors "antibodies". They mature into plasma cells and become fixed in tissues to secrete antibodies "immunoglobulin". T lymphocytes: "Thymus dependent". They become differentiated and mature in thymus in early life. They acquire the ability to recognize and distinguish self from non self "foreign tissues and infections agents".

They are not capable of antibody production. They have the ability of killing "lysis" of virus infected cells and tumour cells. They have specialized surface glycoprotein molecules. They do not reside in a single organ. Lymphocytes have the distinctive feature of recirculation between the blood, tissues and lymphoid organs "Lymphocyte traffic".

Recirculation is not a random process but a highly regulated process of immune surveillance. Sites of development and maturation of lymphocytes. They include spleen and lymph nodes.

This occurs under the influence of soluble mediators such as colony stimulating factors. It increases in size after both until puberty then undergoes involution in adulthood and old age. It has an outer cortex and inner medulla. The cortex contains a heavy concentration of thymocytes Tlymphocytes in the thymus which have arrived from the bone marrow via the blood stream.

The pre-T lymphocytes mature in the cortex of thymus in close association with thymic epithelial cells and macrophage derived cells. The cortex contains follicles which are organized aggregates of lymphoid cells, mainly B lymphocytes, macrophages and follicular dendritic cells. Primary follicles are in a resting state and secondary follicles arise following stimulation of a local immune response and contain germinal centers where B lymphocytes undergo proliferation and differentiation.

The paracortical area of the LN is predominantly composed of T lymphocytes and interdigitating dendritic cells which are accessory cells in T lymphocytes response. The medulla is composed of cords of lymphoid cells in which plasma cells predominate during immune reactions. Lymphocytes enter the L. Through the afferent lymphatic, lymphocytes enter to the subcapsular sinus then travel into the cortex and then the medulla of the L. The speed by which the lymphocytes course through the L.

They leave via efferent lymphatic, ultimately passing through the thoracic duct then into the venous system. Lymphocytes may also, enter the LNs via the blood, via large cuboidal endothelial cells present on specialized structures called high endothelial venules HEV. Lymphocytes require homing receptors on their surfaces to interact with HEVs and such receptors are specific for different lymphocytes and different tissues. Peyer's patches are lymphoid aggregates with follicles, germinal centers and a surrounding T cell area, but they have no capsule or afferent lymphatic.

They are separated from the intestinal lumen by a specialized epithelial cell. Blood supply arrives via the splenic artery which divides into progressively smaller branches, then into arterioles which drain into vascular sinusoids which drain into the venous system. It contains two types of tissues: red pulp and white pulp. The red pulp is composed of reticular tissues and sinuses bathed with blood.

It is an important site for removal of old and defective red and white blood cells where they are engulphed and macrophages. The white pulp is dense lymphoid tissue arranged around a central arteriole. Which is called periarterial lymphotic sheath PAL predominantly T cells zone.

Within the PAL, lymphoid follicles with germinal centres B cell area are found. The spleen is the major site of immune responses to blood born antigens. The slow circulation allows constant monitoring of blood with regard to infectious agents and antigen-antibody complex which signify an active immune response.

Splenectomy may be done because of various reasons e. However, splenectomy is associated with increased risk of infections especially with capsulated organisms e. So, immunity means protection from infection or free from burden of disease. The broad definition of the immune system involves the ability to identify self and recognize non self, including pathogens as well as foreign tissue.

Protection from all these should include a variety of cognitive and destructive processes. Understanding these processes forms the basis of Immunology. Protects from: Bacteria pyogenic organisms , fungi "e. Candida" and worms "multicellular parasites e. It is the first line of defence against invading organisms. Components: a. Physical barriers: Skin and mucosae, secretions which continuously wash and cleans mucus surfaces "e. Mechanical removal also by coughing and sneezing. Colonization resistance: The presence of normal flora in the skin and gut preventing colonization by pathogenic organisms.

Non specific immune response: Immediate acting, directly activated by infectious agents, tissue damage or tumours. Its advantage is rapid action but the disadvantage is being non specific, so, may cause host tissue damage. Opsonins "which help digestion of bacteria by neutrophils e. Proteolytic enzymes e. It is the hall mark of the immune system. It is not present at birth but acquired with antigen exposure "except that acquired by I baby from the mother". There is considerable interaction is innate and specific immune response.

Innate Immunity: Cellular Mechanisms Several cellular mechanisms are present and functional at birth and constitute the innate cellular immune system. The migration into tissues is unidirectional. It is an essential component of the cellular innate system involved in killing bacteria and fungi. They are abundant in bone marrow and blood. They are released from the bone marrow in large numbers during infections and new cells are produced by the action of granulocyte colony stimulating factor GMCSF.

Neutrophil's half life in blood is about 6 hours and in tissues days. Complement components C Leukotrien B4 LTB4 which are macrophage derived products of the lipooxygenase pathway of arachidonic acid metabolism. FMLP a peptide which is a bacterial product.

Cytokines e. These activators cause up regulation of adhesion molecules on the surface of neutrophils and endothelial cells. Adhesion molecules: These are surface proteins which facilitates intercellular adhesion. Their functions include cell activation, cytokine release, capture and. There are 3 main families: selection, integrin and ICAM.

Neutrophils have the capacity to ingest more than one bacterium or fungus at once. When large numbers of phagocytes are involved in an infective process, an abscess filled with pus dead or dying neutrophils may form.

The best opsonins are complementing component C3b, C-reactive protein and antibody i. Then the intracellular phagosome becomes fused to neutrophil granules which releases its contents. O2 dependent mechanism "the respiratory burst", in which there is production of reactive oxygen metabolites such as hydrogen peroxide, hydroxyl radicals, singlet oxygen and superoxide anion.

Recurrent bacterial and fungal infections occur in conditions associated with failure of neutrophil's action e. They are more abundant in tissues where they survive for several weeks. The eosinophil cationic proteins are: major basic protein MBP , eosinophil cationic protein ECP and eosinophil neurotoxin. They are a feature of infiltrate in tissues involved in allergic responses e.

basic immunology book pdf

Access scientific knowledge from anywhere. Special thanks to those whose helps in the production of the book has been indispensable. Klimov Chapter-3 Antigenicity and Immunogens, details the antigenicity and immunogenicity of the antigens in the host and the various types that help in bringing out the advance descriptive knowledge without which we cannot talk on immunity. Frontiers in Cellular and Infection Microbiology. From Basic to Clinical Immunology. Follow by Email. Lecture Notes in Immunology I.

From Basic to Clinical Immunology

This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately — but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with clinical comments that complete the whole picture. Immunology is a complex science, which requires a simplified approach in order to be taught and understood effectively. Reviewing a variety of important components related to the immune system, it is clearly and logically structured, and enriched by figures, tables and boxes with important immunology definitions.

Both basic science and clinical immunology are demystified here for the medical and other health sciences student.


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