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Bioinorganic chemistry is a field that examines the role of metals in biology. Bioinorganic chemistry includes the study of both natural phenomena such as the behavior of metalloproteins as well as artificially introduced metals, including those that are non-essential , in medicine and toxicology. Many biological processes such as respiration depend upon molecules that fall within the realm of inorganic chemistry. The discipline also includes the study of inorganic models or mimics that imitate the behaviour of metalloproteins. As a mix of biochemistry and inorganic chemistry , bioinorganic chemistry is important in elucidating the implications of electron-transfer proteins , substrate bindings and activation, atom and group transfer chemistry as well as metal properties in biological chemistry. The first protein ever crystallized see James B.
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Bioinorganic Chemistry and Applications - Table of contents.
Bioinorganic Chemistry and Applications
S -Nitrosoglutathione GSNO reduces cell viability, inhibits cell division, and induces cell cycle arrest and apoptosis in neuroblastoma cells. Recent studies have shown that inhibition of the hSIRT2 enzyme provides favorable effects in neurodegenerative diseases such as Alzheimer's disease. Uptake of NO by a ruthenium metallodrug is kinetically and thermodynamically feasible, taking place with spin surface crossing. Eight thymol derivatives including three new ones 1—3 were obtained from the aerial parts of Ageratina adenophora , with most of them, in particular 1 and 5 , showing notable in vitro antimicrobial and cytotoxic activity. In recent years, the development of a nano-conjugate system for drug delivery applications has gained attention among researchers.
Written by a preeminent teacher and scientist in the field, Bioinorganic Chemistry provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject. Biosphere Ecosystem 0.
Bioinorganic chemistry is a indisciplinary scientific branch that examines the chemistry of metal-containing compounds within biological and biochemical systems. The organic compounds and molecules are composed predominantly of non-metals. Nevertheless, the metals play a role in life processes.